Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

T. Gewirtz, Andrew; Navas, Tony; Lyons, Sean; J. Godowski, Paul; Madara, James

doi:10.4049/jimmunol.167.4.1882

Public

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Published in The Journal of Immunology • Aug 1, 2001

Authors:

Andrew T. Gewirtz

Tony Navas

Sean Lyons

Abstract

Flagellin, the structural component of bacterial flagella, is secreted by pathogenic and commensal bacteria. Flagellin activates proinflammatory gene expression in intestinal epithelia. However, only flagellin that contacts basolateral epithelial surfaces is proinflammatory; apical flagellin has no ...

Subject

Flagellin

TLR5

Proinflammatory cytokine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!