Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

Lin, Rongtuan; Heylbroeck, Christophe; M. Pitha, Paula; Hiscott, John

doi:10.1128/mcb.18.5.2986

Public

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

Published in Molecular and Cellular Biology • May 1, 1998

Authors:

Rongtuan Lin

Christophe Heylbroeck

Paula M. Pitha

Abstract

The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-alpha/beta) gene promoters, as well as the interferon-stimulated response element (ISRE) of some IFN-stimulated genes. IRF-3 was orig...

Subject

Biology

Promoter

Transactivation

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