Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

Jiang, Wei; M. Lederman, Michael; W. Hunt, Peter; F. Sieg, Scott; P. Haley, Kathryn; Rodríguez, Benigno; Landay, Alan; N. Martin, Jeffrey; Sinclair, Elizabeth; I. Asher, Ava; G. Deeks, Steven; C. Douek, Daniel; M. Brenchley, Jason

doi:10.1086/597476

Public

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

Published in The Journal of Infectious Diseases • Mar 6, 2009

Authors:

Wei Jiang

Michael M. Lederman

Peter W. Hunt

Abstract

The significance of elevated plasma levels of bacterial lipopolysaccharide (LPS) in persons with chronic HIV infection remains undefined. We measured LPS levels by use of limulus lysate assay, and DNA sequences encoding bacterial ribosomal 16S RNA (16S rDNA) were assessed by quantitative polymerase ...

Subject

Immune system

Human immunodeficiency virus (HIV)

Immunology

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