Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.

T, Ishibe; T, Nakayama; T, Okamoto; T, Aoyama; K, Nishijo; KR, Shibata; Y, Shima; S, Nagayama; T, Katagiri; Y, Nakamura; T, Nakamura; J, Toguchida

doi:10.1158/1078-0432.ccr-04-2057

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Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.

Shared by NobleBlocks on Apr 1, 2005 • 12:00 AM UTC

Authors:

Ishibe T

Nakayama T

Okamoto T

Abstract

Purpose Synovial sarcoma is a soft tissue sarcoma, the growth regulatory mechanisms of which are unknown. We investigated the involvement of fibroblast growth factor (FGF) signals in synovial sarcoma and evaluated the therapeutic effect of inhibiting the FGF signal.Experimental design The expression...

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