Identification of a Principal mRNA Species for Human 3 -Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D2 11-Ketoreductase Activity

Matsuura, Katsuhisa; Shiraishi, Hideaki; Hara, Akira; Sato, Kazunobu; Deyashiki, Yoshihiro; Ninomiya, Motoki; Sakai, Shuichi

doi:10.1093/oxfordjournals.jbchem.a022211

Public

Identification of a Principal mRNA Species for Human 3 -Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D2 11-Ketoreductase Activity

Published in The Journal of Biochemistry • Nov 1, 1998

Authors:

Katsuhisa Matsuura

Hideaki Shiraishi

Akira Hara

Abstract

Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4. The properties of AKR1C3 have not been fully characterized compared to the other isoforms. In addition, a cDNA that shows more than 99% homology w...

Subject

Complementary DNA

Aldo-keto reductase

Biology

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