Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, Chunli; Chen, Yan; W. Cline, Gary; Zhang, Dongyan; Zong, Haihong; Wang, Yanlin; Bergeron, Raynald; K. Kim, Jason; W. Cushman, Samuel; J. Cooney, Gregory; Atcheson, Bronwyn; F. White, Morris; W. Kraegen, Edward; I. Shulman, Gerald

doi:10.1074/jbc.m200958200

Public

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Published in Journal of Biological Chemistry • Dec 1, 2002

Authors:

Chunli Yu

Yan Chen

Gary W. Cline

Abstract

Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which fatty acids mediate this effect, rats were in...

Subject

Insulin receptor

Internal medicine

Endocrinology

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