The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

M. Kluck, Ruth; Bossy-Wetzel, Ella; R. Green, Douglas; D. Newmeyer, Donald

doi:10.1126/science.275.5303.1132

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The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Shared by NobleBlocks on Feb 21, 1997 • 12:00 AM UTC

Authors:

Ruth M. Kluck

Ella Bossy-Wetzel

Douglas R. Green

Abstract

In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear morphology. Bcl-2 acted in situ on mitochondria to prevent the release of cytochrome c and thus caspase activation. During apopt...

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