CSF biomarker variability in the Alzheimer's Association quality control program

Mattsson, Niklas; Andréasson, Ulf; Persson, Staffan; C. Carrillo, María; Collins, Steven; Chalbot, Sonia; E. Cutler, Neal; Dufour‐Rainfray, Diane; M. Fagan, Anne; H. H. Heegaard, Niels; Robin Hsiung, Ging‐Yuek; T. Hyman, Bradley; Iqbal, Khalid; Richard Lachno, D.; Lleó, Alberto; Lewczuk, Piotr; Luís Molinuevo, José; Parchi, Piero; Regeniter, Axel; A. Rissman, Robert; Rosenmann, Hanna; Sancesario, Giuseppe; Schröder, Johannes; M. Shaw, Leslie; E. Teunissen, Charlotte; Q. Trojanowski, John; Vanderstichele, Hugo; Vandijck, Manu; M. Verbeek, Marcel; Zetterberg, Henrik; Blennow, Kaj; A. Käser, Stephan; José A. Rojo, Aladro; Albert, Marilyn; Alcolea, Daniel; Andréasson, Ulf; Antonell, Anna; Arai, Hiroyuki; Archetti, Silvana; Lagberg Arkblad, Eva; Baldeiras, Inês; Bartoš, Aleš; Batish, Dev; Bedel, Aurélie; Bentué‐Ferrer, Danièle; Berisha, Flora; Bernardini, Sergio; A. Blankenstein, Marinus; Blennow, Kaj; Bousiges, Olivier; C. Camuso, Michael; Carrillo, Maria; Casoli, Tiziana; Cavallaro, Sebastiano; Chalbot, Sonia; Collins, Steven; Cruz e Silva, Odete; E. Cutler, Neal; Cuvelier, I.; Delaroche, Odile; Dufour‐Rainfray, Diane; B. Dyer, Roy; Engelborghs, Sebastiaan; M. Fagan, Anne; Fogli, Anne; Vicente Forlenza, Orestes; C. Fox, Nick; B. Frisoni, Giovanni; Galimberti, Daniela; Galloni, Elisabetta; Maria Gritti, Silvana; H. Gylys, Karen; Hampel, Harald; Haustein, Sabine; Heath, Theresa; H. H. Heegaard, Niels; T. Heneka, Michael; Herukka, Sanna‐Kaisa; M. Holtzman, David; Robin Hsiung, Ging‐Yuek; Humpel, Christian; T. Hyman, Bradley; Iwatsubo, Takeshi; Iqbal, Khalid; Jardel, Claude; Jucker, Mathias; Kapaki, Elisabeth; A. Käser, Stephan; Kidd, Daniel; Klivènyi, Péter; Kuwano, Ryozo; Richard Lachno, D.; Lamari, Foudil; Laplanche, Jean; Laser, Jordan; Lehmann, Sylvian; Lewczuk, Piotr; Li, Qiao‐Xin; Lleó, Alberto; Maetzler, Walter; Malaplate‐Armand, Catherine; Martin, Ralph; Martone, Robert; L. Masters, Colin; Mattsson, Niklas; Mercken, Marc; Luís Molinuevo, José; Montine, Tom; Nowatzke, William; Otto, Markus; Parchi, Piero; Parent, Xavier; Parnetti, Lucilla; Persson, Staffan; C. Petersen, Ronald; Poesen, Koen; Quadrio, Isabelle; Quillard, Muriel; Regeniter, Axel; Luis Rello, Vara; A. Rissman, Robert; Rohan, Zdeněk; Rosenmann, Hanna; Sancesario, Giuseppe; Schröder, Johannes; M. Shaw, Leslie; Sisowath, Christin; Skinningsrud, Anders; Soares, Holly; Soininen, Hilkka; Cindy Søndersø, Knudsen; Spreer, Annette; Suardi, Silvia; E. Teunissen, Charlotte; Q. Trojanowski, John; M. Umek, Robert; Van Broeck, Bianca; Vandenberghe, Rik; Vanderstichele, Hugo; Vandijck, Manu; Vécsei, László; M. Verbeek, Marcel; Voštiar, Igor; Windisch, Manfred; Zetterberg, Henrik

doi:10.1016/j.jalz.2013.01.010

Public

CSF biomarker variability in the Alzheimer's Association quality control program

Published in Alzheimer s & Dementia • May 1, 2013

Authors:

Niklas Mattsson

Ulf Andréasson

Staffan Persson

Abstract

BACKGROUND: The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories. METHODS: Data fro...

Subject

Biomarker

Immunoassay

Neurochemistry

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