Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling Pathways

Hsu, Hsien‐Yeh; Hua, Kuo‐Feng; Lin, Chun‐Cheng; Lin, Chun‐Hung; Hsu, Jason; Wong, Chi‐Huey

doi:10.4049/jimmunol.173.10.5989

Public

Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling Pathways

Published in The Journal of Immunology • Nov 1, 2004

Authors:

Hsien‐Yeh Hsu

Kuo‐Feng Hua

Chun‐Cheng Lin

Abstract

We have demonstrated that an extract of Ganoderma lucidum (Reishi or Ling-Zhi) polysaccharides (EORP) exerts immunomodulating activities by stimulating the expression of inflammatory cytokines from mouse spleen cells. Interestingly, via responding to LPS in genetic variation of murine macrophage HeN...

Subject

Signal transduction

p38 mitogen-activated protein kinases

TLR4

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