Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening.

KH, Nicolaides; K, Spencer; K, Avgidou; S, Faiola; O, Falcon

doi:10.1002/uog.1860

Public

Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening.

Shared by NobleBlocks on Mar 1, 2005 • 12:00 AM UTC

Authors:

Nicolaides KH

Spencer K

Avgidou K

Abstract

Objectives To evaluate the performance of first-trimester screening for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A). In addition, the potential impa...

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