A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

N. Oxman, Michael; J. Levin, Myron; R. Johnson, Gary; E. Schmader, Kenneth; E. Straus, Stephen; D. Gelb, Lawrence; D. Arbeit, Robert; S. Simberkoff, Michael; A. Gershon, Anne; E. Davis, L.; Weinberg, Adriana; Boardman, K.D.; Williams, Heather; Hongyuan Zhang, J.; Peduzzi, Peter; Beisel, Chris; A. Morrison, V.; C Guatelli, J; A. Brooks, Patricia; A. Kauffman, Carol; T. Pachucki, C.; M. Neuzil, Kathleen; F. Betts, Robert; F. Wright, Peter; R. Griffin, Marie; A. Brunell, P.; E. Soto, Norberto; Marques, Adriana; Keay, S.; Goodman, R.P.; Cotton, D.J.; W. Gnann, J.; Loutit, J.; Holodniy, Mark; Keitel, W; E. Crawford, G.; Yeh, Shing‐Shing; Lobo, Zeena; Toney, John; N. Greenberg, Richard; M. Keller, Paul; Harbecke, Ruth; Hayward, Anthony; R. Irwin, Michael; C. Kyriakides, Tassos; Y. Chan, Christina; S. F. Chan, I.; W. B. Wang, W.; W. Annunziato, Paula; L. Silber, Jeffrey

doi:10.1056/nejmoa051016

Public

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

Published in New England Journal of Medicine • Jun 1, 2005

Authors:

Michael N. Oxman

Myron J. Levin

Gary R. Johnson

Abstract

BACKGROUND: The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or b...

Subject

Postherpetic neuralgia

Medicine

Incidence (geometry)

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