<i>DNMT3A</i> Mutations in Acute Myeloid Leukemia

J. Ley, Timothy; Ding, Li; J. Walter, Matthew; D. McLellan, Michael; Lamprecht, Tamara; E. Larson, David; Kandoth, Cyriac; E. Payton, Jacqueline; Baty, Jack; S. Welch, John; Harris, Christopher; F. Lichti, Cheryl; Reid Townsend, R.; S. Fulton, Robert; J. Dooling, David; C. Koboldt, Daniel; K. Schmidt, Heather; Zhang, Qunyuan; R. Osborne, John; Lin, Ling; D. O’Laughlin, Michelle; F. McMichael, Joshua; D. Delehaunty, Kim; McGrath, Sean; A. Fulton, Lucinda; Magrini, Vincent; L. Vickery, Tammi; Hundal, Jasreet; L. Cook, Lisa; J. Conyers, Joshua; W. Swift, Gary; P. Reed, Jerry; A. Alldredge, Patricia; Wylie, Todd; Walker, Jason; Kalicki, Joelle; A. Watson, Mark; E. Heath, Sharon; D. Shannon, William; Varghese, Nobish; Nagarajan, Rakesh; Westervelt, Peter; H. Tomasson, Michael; C. Link, Daniel; A. Graubert, Timothy; F. DiPersio, John; R. Mardis, Elaine; K. Wilson, Richard

doi:10.1056/nejmoa1005143

Public

DNMT3A Mutations in Acute Myeloid Leukemia

Published in New England Journal of Medicine • Nov 10, 2010

Authors:

Timothy J. Ley

Li Ding

Matthew J. Walter

Abstract

BACKGROUND: The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown. METHODS: Using massively parallel DNA sequencing, we identified a somatic mutation in DNMT3A, encoding a DNA methyltransferase, in the genome of cells from a patient...

Subject

Frameshift mutation

Medicine

Myeloid leukemia

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