A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution

Very high enantioselectivity has been achieved both in the copper-catalyzed alkylation of allylic substrates by Grignard and organozinc reagents and in the iridium-catalyzed amination of cinnamyl carbonate by employing a very efficient phosphoramidite ligand (see scheme).