Identification and characterization of <i>virK</i>, a virulence‐associated large plasmid gene essential for intercellular spreading of <i>Shigella flexneri</i>

Nakata, Noboru; Sasakawa, Chihiro; Okada, Nobuhiko; Tobe, Toru; Fukuda, I.; Suzuki, Toshihiko; Komatsu, K; Yoshikawa, M

doi:10.1111/j.1365-2958.1992.tb01413.x

Public

Identification and characterization of virK, a virulence‐associated large plasmid gene essential for intercellular spreading of Shigella flexneri

Published in Molecular Microbiology • Aug 1, 1992

Authors:

Noboru Nakata

Chihiro Sasakawa

Nobuhiko Okada

Abstract

Seven virulence loci have been identified by Tn5 insertion mutagenesis on the large 230 kb plasmid (pMYSH6000) of Shigella flexneri 2a. In this study, we used Tn10 insertion mutagenesis and identified a novel virulence locus on pMYSH6000 responsible for bacterial spread. Characterization of the inva...

Subject

Biology

Virulence

Shigella flexneri

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