Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

Matteoli, Gianluca; Mazzini, Elisa; D Iliev, Iliyan; Mileti, Erika; Fallarino, Francesca; Puccetti, Paolo; Chieppa, Marcello; Rescigno, Maria

doi:10.1136/gut.2009.185108

Public

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

Published in Gut • May 1, 2010

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Authors:

Gianluca Matteoli

,

Elisa Mazzini

,

Iliyan D Iliev

Abstract

OBJECTIVE: CD103(+) gut dendritic cells (DCs) have been shown to be required for de novo conversion of adaptive T regulatory (Treg) cells. Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in tryptophan catabolism that is expressed by DCs isolated from tumour-draining lymph nodes. IDO-expressi...

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