Cardiomyocytes can be generated from marrow stromal cells in vitro

Makino, Shinji; Fukuda, Keiichi; Miyoshi, Shunichirou; Konishi, Fusako; Kodama, Hiroaki; Pan, Jing; Sano, Motoaki; Takahashi, Toshiyuki; Hori, Shingo; Abe, Hitoshi; Hata, Jun-ichi; Umezawa, Akihiro; Ogawa, Satoshi

doi:10.1172/jci5298

Public

Cardiomyocytes can be generated from marrow stromal cells in vitro

Published in Journal of Clinical Investigation • Mar 1, 1999

Authors:

Shinji Makino

Keiichi Fukuda

Shunichirou Miyoshi

Abstract

We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells. Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells were repeatedly screened. The cells showed a fibroblast-like morphology, but the morphology changed after 5-azacytidin...

Subject

Stromal cell

Myosin

Cell biology

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