IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

Gasse, Paméla; Mary, Caroline; Guénon, Isabelle; Noulin, Nicolas; Charron, Sabine; Schnyder‐Candrian, Silvia; Schnyder, Bruno; Akira, Shizuo; Quesniaux, Valérie; Lagente, Vincent; Ryffel, Bernhard; Couillin, Isabelle

doi:10.1172/jci32285

Public

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

Published in Journal of Clinical Investigation • Nov 8, 2007

Authors:

Paméla Gasse

Caroline Mary

Isabelle Guénon

Abstract

The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1 receptor 1 (IL-1R1) and the common adaptor for Toll/IL-1R signal transduction, MyD88, in this process using a murine model of acute pulmonary injur...

Subject

Bleomycin

Inflammation

Inflammasome

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