NEDD1-dependent recruitment of the γ-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

Haren, Laurence; Remy, Marie‐Hélène; Bazin, Ingrid; Callebaut, Isabelle; Wright, Michel; Merdes, Andreas

doi:10.1083/jcb.200510028

Public

NEDD1-dependent recruitment of the γ-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

Published in The Journal of Cell Biology • Feb 6, 2006

Authors:

Laurence Haren

Marie‐Hélène Remy

Ingrid Bazin

Abstract

The centrosome is the major microtubule organizing structure in somatic cells. Centrosomal microtubule nucleation depends on the protein gamma-tubulin. In mammals, gamma-tubulin associates with additional proteins into a large complex, the gamma-tubulin ring complex (gammaTuRC). We characterize NEDD...

Subject

Centrosome

Centriole

Biology

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