Resveratrol Induces Apoptosis in Thyroid Cancer Cell Lines via a MAPK- and p53-Dependent Mechanism

Shih, Ai; B. Davis, Faith; Lin, Hung‐Yun; J. Davis, Paul

doi:10.1210/jcem.87.3.8345

Public

Resveratrol Induces Apoptosis in Thyroid Cancer Cell Lines via a MAPK- and p53-Dependent Mechanism

Published in The Journal of Clinical Endocrinology & Metabolism • Mar 1, 2002

Authors:

Ai Shih

Faith B. Davis

Hung‐Yun Lin

Abstract

Two papillary thyroid carcinoma (PTC) and two follicular thyroid carcinoma (FTC) cell lines treated with resveratrol (RV), 1-10 microM, showed activation and nuclear translocation of MAPK (extracellular signal-regulated kinase 1/2). Cellular abundance of the oncogene suppressor protein p53, serine p...

Subject

Transfection

MAPK/ERK pathway

Apoptosis

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