Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

Brun, Émilie; Barreau, Frédérick; Veronesi, Giulia; Fayard, Barbara; Sorieul, S.; Chanéac, Corinne; Carapito, Christine; Rabilloud, Thierry; Mabondzo, Aloı̈se; Herlin‐Boime, Nathalie; Carrière, Marie

doi:10.1186/1743-8977-11-13

Public

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

Published in Particle and Fibre Toxicology • Mar 25, 2014

Authors:

Émilie Brun

Frédérick Barreau

Giulia Veronesi

Abstract

BACKGROUND: TiO2 particles are commonly used as dietary supplements and may contain up to 36% of nano-sized particles (TiO2-NPs). Still impact and translocation of NPs through the gut epithelium is poorly documented. RESULTS: We show that, in vivo and ex vivo, agglomerates of TiO2-NPs cross both the...

Subject

Paracellular transport

Ileum

Intestinal epithelium

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