DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Osório, Ana; L. Milne, Roger; Kuchenbaecker, Karoline; Vaclová, Tereza; Pita, Guillermo; Alonso, Rosario; Peterlongo, Paolo; Blanco, Ignacio; de la Hoya, Miguel; Durán, M.; Dı́ez, Orland; Ramón y Cajal, Teresa; Konstantopoulou, Irene; Martínez-Bouzas, Cristina; Andrés Conejero, Raquel; Soucy, Penny; McGuffog, Lesley; Barrowdale, Daniel; Lee, Andrew; , SWE-BRCA; Arver, Brita; Rantala, Johanna; Loman, Niklas; Ehrencrona, Hans; I. Olopade, Olufunmilayo; Beattie, Mary; M. Domchek, Susan; L. Nathanson, Katherine; R. Rebbeck, Timothy; Arun, Banu; Y. Karlan, Beth; Walsh, Christine; Lester, Jenny; M. John, Esther; S. Whittemore, Alice; B. Daly, Mary; C. Southey, Melissa; L. Hopper, John; Beth Terry, Mary; S. Buys, Saundra; Janavičius, Ramūnas; M. Dorfling, Cecilia; J. van Rensburg, Elizabeth; Steele, Linda; L. Neuhausen, Susan; Chun Ding, Yuan; van Overeem Hansen, Thomas; Jønson, Lars; Ejlertsen, Bent; Gerdes, Anne‐Marie; Infante, Mar; Herráez, Belén; Thais Moreno, Leticia; N. Weitzel, Jeffrey; Herzog, Josef; Weeman, Kisa; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Scuvera, Giulietta; Bonanni, Bernardo; Mariette, Frédérique; Volorio, Sara; Viel, Alessandra; Varesco, Liliana; Papi, Laura; Ottini, Laura; Grazia Tibiletti, Maria; Radice, Paolo; Yannoukakos, Drakoulis; Garber, Judy; Ellis, Steve; Frost, Debra; Platte, Radka; Fineberg, Elena; Gareth Evans, D.; Lalloo, Fiona; Izatt, Louise; A. Eeles, Rosalind; Adlard, Julian; Davidson, Rosemarie; Cole, Trevor; Eccles, Diana; Cook, Jackie; Hodgson, Shirley; Brewer, Carole; Tischkowitz, Marc; Douglas, Fiona; Porteous, Mary; Side, Lucy; Walker, Lisa; J. Morrison, Patrick; Donaldson, Alan; Kennedy, John; Foo, Claire; K. Godwin, Andrew; K. Schmutzler, Rita; Wappenschmidt, Barbara; Rhiem, Kerstin; Engel, Christoph; Meindl, Alfons; Ditsch, Nina; Arnold, Norbert; Jörg Plendl, Hans; Niederacher, Dieter; Sutter, Christian; Wang‐Gohrke, Shan; Steinemann, Doris; Preisler-Adams, Sabine; Kast, Karin; Varon-Mateeva, Raymonda; Gehrig, Andrea; Stoppa‐Lyonnet, Dominique; M. Sinilnikova, Olga; Mazoyer, Sylvie; Damiola, Francesca; Poppe, Bruce; Claes, Kathleen; Piedmonte, Marion; Tucker, Kathy; Backes, Floor; C. Rodriguez, Gustavo; R. Brewster, Wendy; Wakeley, Katie; Rutherford, Thomas; Caldés, Trinidad; Nevanlinna, Heli; Aittomäki, Kristiina; A. Rookus, Matti; A.M. van Os, Theo; van der Kolk, Lizet; L. Lange, Jeffrey; Meijers‐Heijboer, Hanne; H. van der Hout, Annemarie; J. van Asperen, Christi; Gómez, E.; Hoogerbrugge, Nicoline; Margriet Collée, J.; H. M. van Deurzen, Carolien; B. van der Luijt, Rob; Devilee, Peter; , HEBON; Oláh, Edith; Lázaro, Conxi; Teulé, Àlex; Menéndez, Mireia; Jakubowska, Anna; Cybulski, Cezary; Gronwald, Jacek; Lubiński, Jan; Durda, Katarzyna; Jaworska–Bieniek, Katarzyna; T. Johannsson, Oskar; Maugard, Christine; Montagna, Marco; Tognazzo, Silvia; R. Teixeira, Manuel; Healey, Sue; Investigators, KConFab; Olswold, Curtis; Guidugli, Lucia; M. Lindor, Noralane; Slager, Susan; I. Szabo, Csilla; Vijai, Joseph; E. Robson, Mark; D. Kauff, Noah; Zhang, Liying; Rau‐Murthy, Rohini; Fink-Retter, A.; F. Singer, Christian; Rappaport, Christine; Geschwantler Kaulich, Daphne; Pfeiler, Georg; Tea, Muy-Kheng; Berger, Andreas; M. Phelan, Catherine; H. Greene, Mark; L. Mai, Phuong; Lejbkowicz, Flavio; L. Andrulis, Irene; Marie Mulligan, Anna; Glendon, Gord; E. Toland, Amanda; Bojesen, Anders; Søkilde Pedersen, Inge; Sunde, Lone; Thomassen, Mads; A. Kruse, Torben; Birk Jensen, Uffe; Friedman, Eitan; Laitman, Yael; Paluch Shimon, Shani; Simard, Jacques; F. Easton, Douglas; Offit, Kenneth; J. Couch, Fergus; Chenevix‐Trench, Georgia; C. Antoniou, Antonis; Benı́tez, Javier

doi:10.1371/journal.pgen.1004256

Public

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Published in PLoS Genetics • Apr 3, 2014

Authors:

Ana Osório

Roger L. Milne

Karoline Kuchenbaecker

Abstract

Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the c...

Subject

DNA glycosylase

Biology

MUTYH

Research Assistant

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