Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

Cindy, S.; J. Hare, Nathan; E. Nichols, Kim; Dupré, Loı̈c; Andolfi, Grazia; Roncarolo, Maria-Grazia; Adelstein, Stephen; D. Hodgkin, Philip; G. Tangye, Stuart

doi:10.1172/jci23139

Public

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

Published in Journal of Clinical Investigation • Mar 3, 2005

Authors:

S. Cindy

Nathan J. Hare

Kim E. Nichols

Abstract

X-linked lymphoproliferative disease (XLP) is an often-fatal immunodeficiency characterized by hypogammaglobulinemia, fulminant infectious mononucleosis, and/or lymphoma. The genetic lesion in XLP, SH2D1A, encodes the adaptor protein SAP (signaling lymphocytic activation molecule-associated [SLAM-as...

Subject

Immunology

Immunity

Humoral immunity

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