Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity.

J, Bastid; A, Regairaz; N, Bonnefoy; C, Déjou; J, Giustiniani; C, Laheurte; S, Cochaud; E, Laprevotte; E, Funck-Brentano; P, Hemon; L, Gros; N, Bec; C, Larroque; G, Alberici; A, Bensussan; JF, Eliaou

doi:10.1158/2326-6066.cir-14-0018

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Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity.

Shared by NobleBlocks on Nov 17, 2014 • 12:00 AM UTC

Authors:

Bastid J

Regairaz A

Bonnefoy N

Abstract

The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. The generation of aden...

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