Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

Wang, Ruobing; L. Doolan, Denise; P. Le, Thong; C. Hedstrom, Richard; Coonan, Kevin; Charoenvit, Yupin; R. Jones, Trevor; Hobart, Peter; Margalith, M; Ng, Jennifer; R. Weiss, Walter; Sedegah, Martha; de Taisne, C.; Norman, Jon; L. Hoffman, Stephen

doi:10.1126/science.282.5388.476

Public

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

Published in Science • Oct 16, 1998

Authors:

Ruobing Wang

Denise L. Doolan

Thong P. Le

Abstract

CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses. Malaria-naïve volunteers who were vaccinated with plasmid DNA encoding a malar...

Subject

Cytotoxic T cell

DNA vaccination

Virology

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