Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Zhang, Geng; He, Peijun; Tan, Hanson; Budhu, Anuradha; Gaedcke, Jochen; Michael Ghadimi, Β.; Ried, Thomas; G. Yfantis, Harris; Ho Lee, Dong; Maitra, Anirban; Hanna, Nader; Richard Alexander, H.; Perwez Hussain, S.

doi:10.1158/1078-0432.ccr-13-0209

Public

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Published in Clinical Cancer Research • Aug 6, 2013

Authors:

Geng Zhang

Peijun He

Hanson Tan

Abstract

PURPOSE: To identify metabolic pathways that are perturbed in pancreatic ductal adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of metabolomics and transcriptomics. EXPERIMENTAL DESIGN: We conducted global metabolite profiling analysis on two independent cohorts of r...

Subject

Pancreatic cancer

Metabolite

Metabolomics

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