Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

Shida, Dai; Fang, Xianjun; Kordula, Tomasz; Takabe, Kazuaki; Lépine, Sandrine; E. Alvarez, Sergio; Milstien, Sheldon; Spiegel, Sarah

doi:10.1158/0008-5472.can-08-0411

Public

Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

Published in Cancer Research • Aug 12, 2008

Authors:

Dai Shida

Xianjun Fang

Tomasz Kordula

Abstract

Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes important for cancer progression. S1P is produced by two sphingosine kinases, SphK1 and SphK2. Expression of SphK1 is elevated in many cancers. Here, we report that LPA markedly...

Subject

Lysophosphatidic acid

Sphingosine kinase 1

Sphingosine

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