Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

K. Griffiths, Emily; M. Krawczyk, Connie; Kong, Young‐Yun; Raab, Monika; J. Hyduk, Sharon; Bouchard, Denis; Chan, Vera; Kozieradzki, I.; Oliveira-dos-Santos, Antonio; Wakeham, Andrew; S. Ohashi, Pamela; I. Cybulsky, Myron; E. Rudd, Christopher; Penninger, Josef

doi:10.1126/science.1063397

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Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

Published in Science • Sep 21, 2001

Authors:

Emily K. Griffiths

Connie M. Krawczyk

Young‐Yun Kong

Abstract

The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Sl...

Subject

T-cell receptor

Adapter (computing)

Cell biology

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