Tolerance and Withdrawal From Prolonged Opioid Use in Critically Ill Children

Anand, K.J.S.; F. Willson, Douglas; Berger, John; Harrison, Rick; L. Meert, Kathleen; J. Zimmerman, Jerry; A. Carcillo, Joseph; J. L. Newth, Christopher; Prodhan, Parthak; Michael Dean, J.; Nicholson, Carol

doi:10.1542/peds.2009-0489

Public

Tolerance and Withdrawal From Prolonged Opioid Use in Critically Ill Children

Published in PEDIATRICS • Apr 19, 2010

Authors:

K.J.S. Anand

Douglas F. Willson

John Berger

Abstract

OBJECTIVE: After prolonged opioid exposure, children develop opioid-induced hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should be based on the mechanisms of opioid tolerance and withdrawal. PATIENTS AND METHODS: Relevant manuscripts published in the English lang...

Subject

Medicine

Opioid

Drug tolerance

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