Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Ross, Jillian; Plummer, Simon; Rode, Anja; Scheer, Nico; C. Bower, Conrad; Vogel, Ortwin; J. Henderson, Colin; Roland Wolf, C.; R. Elcombe, Clifford

doi:10.1093/toxsci/kfq118

Public

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Published in Toxicological Sciences • Apr 19, 2010

Authors:

Jillian Ross

Simon Plummer

Anja Rode

Abstract

Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constit...

Subject

Pregnane X receptor

Constitutive androstane receptor

In vivo

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