Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice

Tomita, Kengo; Tamiya, Gen; Ando, Satoshi; Ohsumi, Kayoko; Chiyo, Tomoko; Mizutani, Akiko; Kitamura, Naoto; Toda, Kyoko; Kaneko, Takehiko; Horie, Yoshinori; Han, J-Y; Kato, Shinzo; Shimoda, Masayuki; Oike, Yuichi; Tomizawa, M.; Makino, Satoshi; Ohkura, Tamiko; Saito, Hidetsugu; Kumagai, Naoki; Nagata, Hiroshi; Ishii, Hiromasa; Hibi, Toshifumi

doi:10.1136/gut.2005.071118

Public

Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice

Published in Gut • Sep 20, 2005

Authors:

Kengo Tomita

Gen Tamiya

Satoshi Ando

Abstract

BACKGROUND: While tumour necrosis factor alpha (TNF-alpha) appears to be associated with the development of non-alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of NASH is not well understood. METHODS: Male mice deficient in both TNF receptors 1 (TNFR1) and 2 (TNFR2) (TNFRDKO m...

Subject

Hepatic stellate cell

Steatohepatitis

Tumor necrosis factor alpha

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