Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

H. Diacon, Andreas; Dawson, Rodney; du Bois, Jeannine; Narunsky, Kim; Venter, Amour; R. Donald, Peter; van Niekerk, Christo; Erondu, Ngozi; M. Ginsberg, Ann; Becker, Piet; Spigelman, Melvin

doi:10.1128/aac.06125-11

Public

Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

Published in Antimicrobial Agents and Chemotherapy • Mar 20, 2012

Authors:

Andreas H. Diacon

Rodney Dawson

Jeannine du Bois

Abstract

PA-824 is a novel nitroimidazo-oxazine under evaluation as an antituberculosis agent. A dose-ranging randomized study was conducted to evaluate the safety, tolerability, pharmacokinetics, and early bactericidal activity of PA-824 in drug-sensitive, sputum smear-positive adult pulmonary-tuberculosis ...

Subject

Medicine

Sputum

Ethambutol

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