American Tegumentary Leishmaniasis: Is Antimonial Treatment Outcome Related to Parasite Drug Susceptibility?

Yardley, Vanessa; Ortuño, Nimer; Llanos‐Cuentas, Alejandro; Chappuis, François; De Doncker, Simonne; Eduardo Ramı́rez, Luı́s; L. Croft, Simon; Arévalo, Jorge; Adaui, Vanessa; Bermúdez, Hernán; Decuypere, Saskia; Dujardin, Jean‐Claude

doi:10.1086/507710

Public

American Tegumentary Leishmaniasis: Is Antimonial Treatment Outcome Related to Parasite Drug Susceptibility?

Published in The Journal of Infectious Diseases • Sep 18, 2006

Authors:

Vanessa Yardley

Nimer Ortuño

Alejandro Llanos‐Cuentas

Abstract

BACKGROUND: Antimonials are the first drug of choice for the treatment of American tegumentary leishmaniasis (ATL); however, their efficacy is not predictable, and this may be linked to parasite drug resistance. We aimed to characterize the in vitro antimony susceptibility of clinical isolates of Pe...

Subject

Amastigote

Leishmaniasis

Drug resistance

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