The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.

Susan A, Farr,; H Fai, Poon,; Dilek, Dogrukol-Ak,; Jeniffer, Drake,; William A, Banks,; Edward, Eyerman,; D Allan, Butterfield,; John E, Morley,

doi:10.1046/j.1471-4159.2003.01580.x

Public

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.

Published in Journal of neurochemistry • Mar 1, 2003

Authors:

Farr, Susan A

Poon, H Fai

Dogrukol-Ak, Dilek

Abstract

Oxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, alpha-lipoic acid (LA) and N-acetylcysteine (NAC), to reverse the cognitive deficits found in the SAMP8 mouse. By 12 months of age, this strain develops elevated le...

Subject

Acetylcysteine

Age Factors

Amyloid beta-Peptides

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