Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition

Significance Our study shows that pyruvate kinase M2 (PKM2), an alternatively spliced variant of the pyruvate kinase gene, mediates epithelial–mesenchymal transition (EMT), which is critical for cancer cells to acquire invasive potential. Our study demonstrates that EMT stimulates nuclear translocat... View More