Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

L. Anderson, Peter; V. Glidden, David; Liu, Albert; Buchbinder, Susan; R. Lama, Javier; V. Guanira, Juan; McMahan, Vanessa; R. Bushman, Lane; Casapía, Martín; Montoya-Herrera, Orlando; G. Veloso, Valdiléa; H. Mayer, Kenneth; Chariyalertsak, Suwat; Schechter, Mauro; Bekker, Linda‐Gail; G. Kallás, Esper; M. Grant, Robert; the iPrEx Study Team, For

doi:10.1126/scitranslmed.3004006

Public

Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

Published in Science Translational Medicine • Sep 12, 2012

Authors:

Peter L. Anderson

David V. Glidden

Albert Liu

Abstract

Drug concentrations associated with protection from HIV-1 acquisition have not been determined. We evaluated drug concentrations among men who have sex with men in a substudy of the iPrEx trial (1). In this randomized placebo-controlled trial, daily oral doses of emtricitabine/tenofovir disoproxil f...

Subject

Emtricitabine

Tenofovir

Pre-exposure prophylaxis

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