β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, Robert; D. Bennett, Brian; Babu‐Khan, Safura; Kahn, Steve; A. Mendiaz, Elizabeth; Denis, Paul; B. Teplow, David; L. Ross, Sandra; Amarante, Patricia; Loeloff, Richard; Luo, Yi; Fisher, Seth; Fuller, Janis; Edenson, Steven; Lile, Jackson; A. Jarosinski, Mark; Leona Biere, Anja; Curran, Eileen; L. Burgess, Teresa; Louis, Jean-Claude; M. Collins, Frank; Treanor, James; N. Rogers, Gary; Citron, Martin

doi:10.1126/science.286.5440.735

Public

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Published in Science • Oct 22, 1999

Authors:

Robert Vassar

Brian D. Bennett

Safura Babu‐Khan

Abstract

Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic tar...

Subject

Proteases

Amyloid precursor protein secretase

Amyloid precursor protein

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