Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease for Pleural Infection. An Effective and Safe Alternative to Surgery

Lo Piccolo, Francesco; Pitman, Nicholas; Bhatnagar, Rahul; Popowicz, Natalia; Smith, Nicola; Brockway, Ben; Nickels, Robert; Burke, Andrew; Wong, Conroy; J. McCartney, Ruth; Choo‐Kang, Brian; G. Blyth, Kevin; Maskell, Nick; Lee, Gary

doi:10.1513/annalsats.201407-329oc

Public

Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease for Pleural Infection. An Effective and Safe Alternative to Surgery

Published in Annals of the American Thoracic Society • Oct 8, 2014

Authors:

Francesco Lo Piccolo

Nicholas Pitman

Rahul Bhatnagar

Abstract

RATIONALE: Intrapleural tissue plasminogen activator (tPA)/deoxyribonuclease (DNase) therapy for pleural infection given at the time of diagnosis has been shown to significantly improve radiological outcomes. Published cases are limited to only a single randomized controlled trial and a few case rep...

Subject

Medicine

Interquartile range

Surgery

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