Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice

Dioszeghy, Vincent; Mondoulet, Lucie; Dhelft, Véronique; Ligouis, Mélanie; Puteaux, Emilie; Benhamou, Pierre‐Henri; Dupont, Christophe

doi:10.4049/jimmunol.1003134

Public

Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice

Published in The Journal of Immunology • Apr 14, 2011

Authors:

Vincent Dioszeghy

Lucie Mondoulet

Véronique Dhelft

Abstract

Epicutaneous immunotherapy onto intact skin has proved to be an efficient and safe alternative treatment of allergy in an animal model with various allergens and in children for cow's milk allergy. The aim of this study was to analyze the different steps of the immunological handling of the allergen...

Subject

Immunology

Allergen

Sensitization

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