The Genetic Landscape of a Cell

Costanzo, Michael; Baryshnikova, Anastasia; Bellay, Jeremy; Kim, Yungil; D. Spear, Eric; S. Sevier, Carolyn; Ding, Huiming; L.Y. Koh, Judice; Toufighi, Kiana; Mostafavi, Sara; Prinz, Jeany; P. St.Onge, Robert; VanderSluis, Benjamin; Makhnevych, Taras; J. Vizeacoumar, Franco; Alizadeh, Solmaz; Bahr, Sondra; L. Brost, Renée; Chen, Yiqun; Cokol, Murat; Deshpande, Raamesh; Li, Zhijian; Lin, Zhen-Yuan; Liang, Wendy; Marback, Michaela; Paw, Jadine; San Luis, Bryan-Joseph; Shuteriqi, Ermira; H.Y. Tong, Amy; van Dyk, Nydia; M. Wallace, Iain; A. Whitney, Joseph; T. Weirauch, Matthew; Zhong, Guoqing; Zhu, Hongwei; A. Houry, Walid; Brudno, Michael; Ragibizadeh, Sasan; Papp, Balázs; Pál, Csaba; P. Roth, Frederick; Giaever, Guri; Nislow, Corey; G. Troyanskaya, Olga; Bussey, Howard; D. Bader, Gary; Gingras, Anne‐Claude; Morris, Quaid; M. Kim, Philip; A. Kaiser, Chris; L. Myers, Chad; Andrews, Brenda; Boone, Charles

doi:10.1126/science.1180823

Public

The Genetic Landscape of a Cell

Published in Science • Jan 21, 2010

Authors:

Michael Costanzo

Anastasia Baryshnikova

Jeremy Bellay

Abstract

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic inter...

Subject

Biology

Pleiotropy

Gene

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