Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.

CT, Happi; GO, Gbotosho; OA, Folarin; A, Sowunmi; T, Hudson; M, O'Neil; W, Milhous; DF, Wirth; AM, Oduola

doi:10.1128/aac.00968-08

Public

Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.

Shared by NobleBlocks on Dec 15, 2008 • 12:00 AM UTC

Authors:

Happi CT

Gbotosho GO

Folarin OA

Abstract

We assessed Plasmodium falciparum mdr1 (Pfmdr1) gene polymorphisms and copy numbers as well as P. falciparum Ca(2+) ATPase (PfATPase6) gene polymorphisms in 90 Nigerian children presenting with uncomplicated falciparum malaria and enrolled in a study of the efficacy of artemether-lumefantrine (AL). ...

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