Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

B. Holcomb, John; C. Tilley, Barbara; Baraniuk, Sarah; E. Fox, Erin; E. Wade, Charles; M. Podbielski, Jeanette; J. del Junco, Deborah; J. Brasel, Karen; M. Bulger, Eileen; A. Callcut, Rachael; J. Cohen, Mitchell; A. Cotton, Bryan; C. Fabian, Timothy; Inaba, Kenji; D. Kerby, Jeffrey; Muskat, Peter; O’Keeffe, Terence; Rizoli, Sandro; R. H. Robinson, Bryce; M. Scalea, Thomas; A. Schreiber, Martin; M. Stein, Deborah; A. Weinberg, Jordan; Callum, Jeannie; R. Hess, John; Matijevic, Nena; N. Miller, Christopher; Pittet, Jean‐François; B. Hoyt, David; D. Pearson, Gail; G. Leroux, Brian; van Belle, Gerald

doi:10.1001/jama.2015.12

Public

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

Published in JAMA • Feb 3, 2015

Authors:

John B. Holcomb

Barbara C. Tilley

Sarah Baraniuk

Abstract

IMPORTANCE: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation, has been associated with improved outcomes; however, there h...

Subject

Medicine

Blood product

Resuscitation

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