Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

Kimura, Kuniko; Iwano, Masayuki; F. Higgins, Debra; Yamaguchi, Yukinari; Nakatani, Kimihiko; Harada, Koji; Kubo, Atsushi; Akai, Yasuhiro; B. Rankin, Erinn; G. Neilson, Eric; H. Haase, Volker; Saito, Yoshihiko

doi:10.1152/ajprenal.90209.2008

Public

Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

Published in American Journal of Physiology-Renal Physiology • Jul 31, 2008

Authors:

Kuniko Kimura

Masayuki Iwano

Debra F. Higgins

Abstract

Chronic hypoxia accelerates renal fibrosis. The chief mediator of the hypoxic response is hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1alpha. HIF-1 regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. To determine the specific ro...

Subject

Fibrosis

Cancer research

Hypoxia-inducible factors

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