Differences in Macrophage Activation by Bacterial DNA and CpG-Containing Oligonucleotides

L. Roberts, Tara; A. Dunn, Jasmyn; D. Terry, Tamsin; P. Jennings, Michael; Hume, David; J. Sweet, Matthew; J. Stacey, Katryn

doi:10.4049/jimmunol.175.6.3569

Public

Differences in Macrophage Activation by Bacterial DNA and CpG-Containing Oligonucleotides

Published in The Journal of Immunology • Sep 1, 2005

Authors:

Tara L. Roberts

Jasmyn A. Dunn

Tamsin D. Terry

Abstract

Bacterial DNA activates mouse macrophages, B cells, and dendritic cells in a TLR9-dependent manner. Although short ssCpG-containing phosphodiester oligonucleotides (PO-ODN) can mimic the action of bacterial DNA on macrophages, they are much less immunostimulatory than Escherichia coli DNA. In this s...

Subject

Oligonucleotide

CpG site

Macrophage

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