Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

Ritchie, Craig; I. Bush, Ashley; Mackinnon, Andrew; Macfarlane, Steve; Mastwyk, Maree; MacGregor, Lachlan; Kiers, Lyn; A. Cherny, Robert; Li, Qiao‐Xin; Tammer, Amanda; Carrington, Darryl; Mavros, Christine; Volitakis, Irene; Xilinas, Michel; Ames, David; N. Davis, Stephen; Beyreuther, Konrad; E. Tanzi, Rudolph; L. Masters, Colin

doi:10.1001/archneur.60.12.1685

Public

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

Published in Archives of Neurology • Dec 1, 2003

Authors:

Craig Ritchie

Ashley I. Bush

Andrew Mackinnon

Abstract

BACKGROUND: Alzheimer disease (AD) may be caused by the toxic accumulation of beta-amyloid (Abeta). OBJECTIVE: To test this theory, we developed a clinical intervention using clioquinol, a metal-protein-attenuating compound (MPAC) that inhibits zinc and copper ions from binding to Abeta, thereby pro...

Subject

Clioquinol

Alzheimer's disease

Placebo

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