Coupling Endoplasmic Reticulum Stress to the Cell Death Program

V. Rao, Rammohan; Hermel, Evan; Castro‐Obregón, Susana; del Rio, Gabriel; Ellerby, Lisa; Michael Ellerby, H.; E. Bredesen, Dale

doi:10.1074/jbc.m102225200

Public

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

Published in Journal of Biological Chemistry • Sep 1, 2001

Authors:

Rammohan V. Rao

Evan Hermel

Susana Castro‐Obregón

Abstract

The endoplasmic reticulum (ER) is the site of assembly of polypeptide chains destined for secretion or routing into various subcellular compartments. It also regulates cellular responses to stress and intracellular Ca(2+) levels. A variety of toxic insults can result in ER stress that ultimately lea...

Subject

Endoplasmic reticulum

Unfolded protein response

Cell biology

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