Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study

Roetzer, Andreas; Diel, Roland; A. Kohl, Thomas; Rückert, Christian; Nübel, Ulrich; Blom, Jochen; Wirth, Thierry; Jaenicke, Sebastian; Schuback, Sieglinde; Rüsch–Gerdes, Sabine; Supply, Philip; Kalinowski, Jörn; Niemann, Stefan

doi:10.1371/journal.pmed.1001387

Public

Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study

Published in PLoS Medicine • Feb 12, 2013

Authors:

Andreas Roetzer

Roland Diel

Thomas A. Kohl

Abstract

BACKGROUND: Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient discriminatory power to resolve large outbreaks. Here, we tested the potential of using next generation genome sequencin...

Subject

Genotyping

Outbreak

Biology

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