Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

S. Steelman, Linda; H. Chappell, William; L. Abrams, Stephen; Kempf, Christian; M. Long, Jacquelyn; Laidler, Piotr; Mijatović, Sanja; Maksimović‐Ivanić, Danijela; Stivala, Franca; Clorinda Mazzarino, María; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Nicoletti, Ferdinando; Libra, Massimo; Milella, Michèle; Tafuri, Agostino; Bonati, Antonio; Bäsecke, Jörg; Cocco, Lucio; Evangelisti, Camilla; M. Martelli, Alberto; Montalto, Giuseppe; Cervello, Melchiorre; A. McCubrey, James

doi:10.18632/aging.100296

Public

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Published in Aging • Mar 10, 2011

Authors:

Linda S. Steelman

William H. Chappell

Stephen L. Abrams

Abstract

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically asso...

Subject

PTEN

PI3K/AKT/mTOR pathway

MAPK/ERK pathway

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