Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Amadesi, Silvia; Nie, Jingjiang; Vergnolle, Nathalie; S. Cottrell, Graeme; F. Grady, Eileen; Trevisani, Marcello; Manni, Chiara; Geppetti, Pierangelo; A. McRoberts, James; S. Ennes, Helena; B. Davis, John; A. Mayer, Emeran; W. Bunnett, Nigel

doi:10.1523/jneurosci.5679-03.2004

Public

Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Published in Journal of Neuroscience • May 5, 2004

Authors:

Silvia Amadesi

Jingjiang Nie

Nathalie Vergnolle

Abstract

Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR2) on spinal afferent neurons and cause persistent inflammation and hyperalgesia by unknown mechanisms. We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel ...

Subject

TRPV1

Hyperalgesia

Chemistry

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