MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

Hou, Jin; Wang, Pin; Lin, Li; Liu, Xingguang; Ma, Feng; An, Huazhang; Wang, Zhugang; Cao, Xuetao

doi:10.4049/jimmunol.0900707

Public

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

Published in The Journal of Immunology • Jul 14, 2009

Authors:

Jin Hou

Pin Wang

Li Lin

Abstract

Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I (RIG-I)- like helicases, cells are activated to produce type I IFN and proinflammatory cytokines. These pathways are tightly regulated by host to prevent inappropriate cellular re...

Subject

Vesicular stomatitis virus

RIG-I

microRNA

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