Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors

Han, Youqi; S. Runge, Marschall; R. Brasier, Allan

doi:10.1161/01.res.84.6.695

Public

Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors

Published in Circulation Research • Apr 2, 1999

Authors:

Youqi Han

Marschall S. Runge

Allan R. Brasier

Abstract

Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells (VSMCs) that functions as an autocrine growth factor. In this study, we analyze the mechanism for Ang II-inducible IL-6 expression in quiescent rat VSMCs. Stimulation with ...

Subject

Angiotensin II

Vascular smooth muscle

Transcription factor

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